Synthetic study of tautomycin. I. Synthesis and regioselective enzymatic acetylationof a spiroketal diol related to the C5-C16 fragment

Article abstract of DOI:10.1016/S0040-4039(97)01118-0

Spiroketal diol 1 was prepared from 5, which can be obtained by enantio-selective enzymatic acetylation of meso diol 6, in 12 steps in 16.5% total yield and its regioselective protection was achieved by an enzymatic method to give 1 6 in high yield.