The Effects of Substituents Introduced into 9-Aminoacridine on Frameshift Mutagenicity and DNA Binding Affinity

Article abstract of DOI:10.1271/bbb.61.1121

Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA bind

Full text of DOI:10.1271/bbb.61.1121

This article was downloaded by: [University of North Carolina]
On: 10 November 2014, At: 15:10
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer
House, 37-41 Mortimer Street, London W1T 3JH, UK
Bioscience, Biotechnology, and Biochemistry
Publication details, including instructions for authors and subscription information:
http://www.tandfonline.com/loi/tbbb20
The Effects of Substituents Introduced into 9-
Aminoacridine on Frameshift Mutagenicity and DNA
Binding Affinity
Hideyuki Tomosakaa, Saburo Omataa, Eietsu Hasegawab & Kentaro Anzaic
a Department of Biosystem Science, Graduate School of Science and Technology,
Igarashi, Niigata, Niigata 950–21, Japan
b Department of Chemistry, Faculty of Science, Niigata University, Igarashi, Niigata,
Niigata 950–21, Japan
c Department of Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka,
Shinjuku-ku, Tokyo 162, Japan
Published online: 12 Jun 2014.
To cite this article: Hideyuki Tomosaka, Saburo Omata, Eietsu Hasegawa & Kentaro Anzai (1997) The Effects of
Substituents Introduced into 9-Aminoacridine on Frameshift Mutagenicity and DNA Binding Affinity, Bioscience,
Biotechnology, and Biochemistry, 61:7, 1121-1125, DOI: 10.1271/bbb.61.1121
To link to this article: http://dx.doi.org/10.1271/bbb.61.1121
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained
in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no
representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of
the Content. Any opinions and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied
upon and should be independently verified with primary sources of information. Taylor and Francis shall
not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other
liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or
arising out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any substantial or systematic
reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any
form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http://
www.tandfonline.com/page/terms-and-conditions

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service