Bioorganic and Medicinal Chemistry Letters p. 2491 - 2496 (1999)
Update date:2022-08-05
Topics:
Russell, Michael G. N.
Beer, Margaret S.
Stanton, Josephine A.
Sohal, Bindi
Mortishire-Smith, Russell J.
Castro, Jose L.
The conformational restriction of a (benzylamino)methyl substituted pyrrolidine to form 2,7-diazabicyclo[3.3.0]octanes has led to a series of compounds with high affinity at the h5-HT(1D) receptor as well as dramatically increased concentrations in the hepatic portal vein following oral administration.
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