Bioorganic and Medicinal Chemistry Letters p. 1847 - 1850 (1997)
Update date:2022-07-30
Topics:
Zhang, Lijun
Williams, Matthew A.
Mendel, Dirk B.
Escarpe, Paul A.
Kim, Choung U.
The influence of C2-substitution of GS 4071 on the influenza neuraminidase inhibitory activity was investigated. The introduction of lipophilic substituents (chloro, methyl, and methylthio) at the C2 position resulted in a significant decrease of the activity. This result indicates that at the enzyme active site there is limited hydrophobic pocket for a group at the C2 position of GS 4071.
View Morewebsite:http://www.hope-chem.com
Contact:86-21-58090396-805
Address:Floor 4, Building 5, No.588 Tianxiong Road, Zhoupu International Medical Zone, ShangHai, China
ZUNYI CITY BEI YUAN CHEMICAL CO., LTD
website:http://www.china-beiyuan.com
Contact:+86-851-27751258
Address:Shawan Town, Huichuan District, Zunyi City, Guizhou Province, China
JIANGXI AIFEIMU TECHNOLOGY CO.，LTD
Contact:+86-570-6040289
Address:FINECHEMICAL PARK,ZIBU TOWN,WANNIAN COUNTY,JIANGXI PROV.,CHINA,ZIP
ShangHai BMG Chemical Co., Ltd
Contact:+86-13524845543
Address:Room 602, no 291 sikai road shanghai
Contact:+86-570-4336358
Address:No.87 Building,Tianqian,Sidu Town
Doi:10.1021/jm970251r
(1997)Doi:10.1016/0040-4020(79)80125-8
(1979)Doi:10.1021/ja971383c
(1997)Doi:10.1016/0031-9422(88)80486-2
(1988)Doi:10.1021/om970480b
(1997)Doi:10.1002/hlca.19970800509
(1997)
