Bioorganic and Medicinal Chemistry Letters p. 1847 - 1850 (1997)
Update date:2022-07-30
Topics:
Zhang, Lijun
Williams, Matthew A.
Mendel, Dirk B.
Escarpe, Paul A.
Kim, Choung U.
The influence of C2-substitution of GS 4071 on the influenza neuraminidase inhibitory activity was investigated. The introduction of lipophilic substituents (chloro, methyl, and methylthio) at the C2 position resulted in a significant decrease of the activity. This result indicates that at the enzyme active site there is limited hydrophobic pocket for a group at the C2 position of GS 4071.
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Doi:10.1021/jm970251r
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(1997)
