The synthesis of novel modified nucleic acid monomers and their subsequent solid phase oligomerisation to give 3'-methylene phosphonate DNA (3MP)

Article abstract of DOI:10.1080/10426509908546327

A protected hypophosphorus acid synthon allowed selective monoalkylation of hypophosphorus acid with 3'-iodo-methylene thymidine. The resulting H-phosphonous acid was an effective monomer for the solid phase synthesis of 3MP DNA which displayed strong binding to complementary RNA.

Full text of DOI:10.1080/10426509908546327

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Phosphorus, Sulfur, and
Silicon and the Related
Elements
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The Synthesis of Novel
Modified Nucleic Acid
Monomers and their
Subsequent Solid Phase
Oligomerisation to
Give 3'-Methylene
Phosphonate DNA (3MP)
Stephen P. Collingwood , Mark E.
Douglas , Francois Natt & Uwe Pieles
a Novartis Pharmaceuticals, Horsham
Research Centre, Wimblehurst Road,
Horsham, UK and Switzerland
b Novartis Pharmaceuticals, Horsham
Research Centre, Wimblehurst Road,
Horsham, UK and Switzerland
c Novartis Pharmaceuticals, Basle,
Switzerland
d Novartis Pharmaceuticals, Basle,
Switzerland
Published online: 17 Mar 2008.

To cite this article: Stephen P. Collingwood , Mark E. Douglas , Francois
Natt & Uwe Pieles (1999) The Synthesis of Novel Modified Nucleic Acid
Monomers and their Subsequent Solid Phase Oligomerisation to Give 3'-
Methylene Phosphonate DNA (3MP), Phosphorus, Sulfur, and Silicon and the
Related Elements, 144:1, 645-648, DOI: 10.1080/10426509908546327
To link to this article: http://dx.doi.org/10.1080/10426509908546327
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