Synthesis of L-ribofuranosyl C-nucleosides

Article abstract of DOI:10.1016/S0008-6215(97)00143-2

C-Nucleosides, 4-amino-8-(β-L-ribofuranosyl)pyrazolo[1,5-α]-1,3,5-triazine (12) and 4-amino-7-( β-L-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidine (L-9-deazaadenosine, 22), were synthesized from the key intermediate, 3 -dimethylamino-2-(2,3-O-isopropylidene-5-O-trityl-L-ribofuranosyl)acrylonitrile (8), which was prepared from L-xylose in 11 steps.