Inhibition of UDP-Gal mutase and mycobacterial galactan biosynthesis by pyrrolidine analogues of galactofuranose

DOI: 10.1016/S0040-4039(97)01539-6

Source and publish data:

Tetrahedron Letters p. 6733 - 6736 (1997)

Update date:2022-07-30

Topics:

Authors:

Lee, Richard E

Smith, Martin D.

Nash, Robert J.

Griffiths, Rhodri C.

McNeil, Michael

Grewal, Ravinder K.

Yan, Wenxin

Besra, Gurdyal S.

Brennan, Patrick J.

Fleet, George W.J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(97)01539-6

Some pyrrolidine analogues of galactofuranose - synthesised from carbohydrate lactones - are the first known inhibitors of E. coli K12 UDP-Gal mutase and mycobacterial galactan biosynthesis. This inhibition may form chemotherapeutic strategy for the treatment of human pathogens which contain integral galactofuranosyl structures such as tuberculosis and leprosy.

Full text of DOI:10.1016/S0040-4039(97)01539-6

Products guided by the article

Product name:(2S,3S,4S)-1-Benzyl-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pyrrolidine

Cas No:196494-84-5

R&D Labs maybe for 196494-84-5

Foreschem Co., Ltd

Contact:+86-533-3112891

Address:zibo
Kono Chem Co.,Ltd

website:http://www.konochem.com

Contact:86-29-86107037

Address:No.170 West Avenue,Xi’an 710082,China
Linyi VIHO Chemical Co.,Ltd

Contact:86-15588110016

Address:LINYI CITY,SHANDONG PROVINCE,CHINA
Suzhou Howsine Biological Technology Co.,Ltd(expird)

website:http://www.howsine.com

Contact:86-512-67262751

Address:No 3,Weihua Road ,Suzhou Industrial Park ,Jiangsu ,China.
Nantong Chem-land Co., Ltd.

Contact:86 513 85512619

Address:Rm.1306, Building A, Wenfeng Mansion,168 Gongnong Road, Nantong Jiangsu China

Relevant to this article

Inhibition of cancer-associated mutant isocitrate dehydrogenases: Synthesis, structure-activity relationship, and selective antitumor activity

Doi:10.1021/jm500660f
(2014)
Total synthesis of (+)-mycotrienol and (+)-mycotrienin I

Doi:10.1021/jo971793j
(1997)
Niobium-mercury heterometallic compounds as sources of niobium(II): Radical paths to organoniobium species

Doi:10.1021/om970779u
(1997)
Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer

Doi:10.1016/j.ejmech.2020.112322
(2020)
Synthesis of β-hydroxy-α-amino acids with a reengineered alanine racemase

Doi:10.1016/j.bmcl.2008.08.031
(2008)
A phenoxazine-based fluorescent chemosensor for dual channel detection of Cd²⁺ and CN^? ions and its application to bio-imaging in live cells and zebrafish

Doi:10.1016/j.dyepig.2019.107828
(2020)

Article Doi