Inhibition of UDP-Gal mutase and mycobacterial galactan biosynthesis by pyrrolidine analogues of galactofuranose

DOI: 10.1016/S0040-4039(97)01539-6

Source and publish data:

Tetrahedron Letters p. 6733 - 6736 (1997)

Update date:2022-07-30

Topics:

Authors:

Lee, Richard E

Smith, Martin D.

Nash, Robert J.

Griffiths, Rhodri C.

McNeil, Michael

Grewal, Ravinder K.

Yan, Wenxin

Besra, Gurdyal S.

Brennan, Patrick J.

Fleet, George W.J.

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Article abstract of DOI:10.1016/S0040-4039(97)01539-6

Some pyrrolidine analogues of galactofuranose - synthesised from carbohydrate lactones - are the first known inhibitors of E. coli K12 UDP-Gal mutase and mycobacterial galactan biosynthesis. This inhibition may form chemotherapeutic strategy for the treatment of human pathogens which contain integral galactofuranosyl structures such as tuberculosis and leprosy.

Full text of DOI:10.1016/S0040-4039(97)01539-6

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