Tetrahedron Letters p. 6733 - 6736 (1997)
Update date:2022-07-30
Topics:
Lee, Richard E
Smith, Martin D.
Nash, Robert J.
Griffiths, Rhodri C.
McNeil, Michael
Grewal, Ravinder K.
Yan, Wenxin
Besra, Gurdyal S.
Brennan, Patrick J.
Fleet, George W.J.
Some pyrrolidine analogues of galactofuranose - synthesised from carbohydrate lactones - are the first known inhibitors of E. coli K12 UDP-Gal mutase and mycobacterial galactan biosynthesis. This inhibition may form chemotherapeutic strategy for the treatment of human pathogens which contain integral galactofuranosyl structures such as tuberculosis and leprosy.
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Doi:10.1021/jm500660f
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