A simple synthesis of the natural 2,5-dialkylresorcinol free radical scavenger antioxidant: Resorstatin

Article abstract of DOI:10.1080/00397919708007301

3,5-Dimethoxybenzoic acid 3 has been transformed into olivetol dimethyl ether 6 in three steps in 79% yield. Directed ortho-metallation-alkylation of 6, followed by boron tribromide demethylation resulted in a simple and inexpensive synthesis of resorstatin, in 70% overall yield from 3.

Full text of DOI:10.1080/00397919708007301

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Synthetic Communications: An
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Organic Chemistry
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A Simple Synthesis of the
Natural 2,5-Dialkylresorcinol
Free Radical Scavenger
Antioxidant: Resorstatin
Sébastien Combes a & Jean-Pierre Finet a
a Laboratoire Chimie, Biologie et Radicaux Libres,
UMR - CNRS 6517 Faculté des Sciences Saint-Jérome,
13397, Marseille, Cedex 20, France
Published online: 22 Aug 2006.
To cite this article: Sbastien Combes & Jean-Pierre Finet (1997) A Simple Synthesis
of the Natural 2,5-Dialkylresorcinol Free Radical Scavenger Antioxidant: Resorstatin,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 27:21, 3769-3778, DOI: 10.1080/00397919708007301
To link to this article: http://dx.doi.org/10.1080/00397919708007301
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