Stereochemical analysis of higher α,α-dialkylglycine containing peptides. Characterization of local helical conformations at dipropylglycine residues and observation of a novel hydrated multiple β-turn structure in crystals of a glycine rich peptide

Article abstract of DOI:10.1021/ja970596z

The peptide Boc-Gly-Dpg-Gly-Gly-Dpg-Gly-NHMe (1) has been synthesized to examine the conformational preferences of Dpg residues in the context of a poor helix promoting sequence. Single crystals of 1 were obtained in the space group P2₁/c with