A new route to quinolone and indole skeletones via ketone- and ester-imide cyclodehydration reactions

DOI: 10.3987/COM-96-7676

Source and publish data:

Heterocycles p. 1979 - 1988 (1997)

Update date:2022-08-02

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Authors:

Kim, Guncheol

Keum, Gyochang

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Article abstract of DOI:10.3987/COM-96-7676

Ketone-imide cyclodehydration reactions of aromatic succinimide and phthalimide (7, 8) have afforded quinolone acids (11, 12). Further transformation of the acids provided the corresponding esters (13, 14) and vinylogous urethanes (9, 10). Similarly, ester-imide cyclodehydration reactions of aromatic imide esters (19, 20) have afforded indole acids (23, 24).

Full text of DOI:10.3987/COM-96-7676

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Product name:[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-phenyl]-acetic acid methyl ester

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