Enantioselective synthesis of the C1-C28 portion of the cytotoxic natural product, amphidinolide B1

DOI: 10.1016/S0040-4039(97)10103-4

Source and publish data:

Tetrahedron Letters p. 7909 - 7910 (1997)

Update date:2022-08-03

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Authors:

Lee, Duck-Hyung

Lee, Suk-Won

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Article abstract of DOI:10.1016/S0040-4039(97)10103-4

The C1-C28 portion of the cytotoxic natural product, amphidinolide B1 (1a), was synthesized enantioselectively using as key steps Evans chiral oxazolidinone chemistry, Sharpless asymetric epoxidation, and the orthoester Claisen rearrangement. The overall

Full text of DOI:10.1016/S0040-4039(97)10103-4

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Product name:(4S,5R)-3-((R)-4-Bromo-2-methyl-pent-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one

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