Synthesis and structure-activity relationship of C-3 quaternary ammonium cephalosporins exhibiting anti-MRSA activities

DOI: 10.1016/S0960-894X(97)10078-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2753 - 2758 (1997)

Update date:2022-07-30

Topics:

Authors:

Kim, Oak K.

Hudyma, Thomas W.

Matiskella, John D.

Ueda, Yasutsugu

Bronson, Joanne J.

Mansuri, Muzammil M.

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Article abstract of DOI:10.1016/S0960-894X(97)10078-6

A series of cephalosporins bearing C-3 quaternary ammonium groups were prepared and evaluated for their anti-MRSA activity. They exhibit good to excellent in vitro activity (MICs= 1-8 μg/mL) against MRSA.

Full text of DOI:10.1016/S0960-894X(97)10078-6

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