2,3-Dimethyl-7-methoxy-6-aminoindole in the synthesis of linear pyrroloquinolines

Article abstract of DOI:10.1007/BF02290748

The possibility of using 2,3-dimethyl-7-methoxy-6-aminoindole for the production of pyrroloquinolines was studied.It was established that the methoxy group at position 7 activates the closure of the pyridine ring with the formation of linearly fused pyrroloquinolines in the Combe reaction, under the conditions of the Vilsmeier reaction and of the thermal cyclization of aminocrotonate, and in the high-temperature cyclization of aminomethylenemalonate.