The effects of N-methylation on the enantioselectivity of catalysis by cyclo[(R)-His-(R)-Phe]

Article abstract of DOI:10.1016/S0957-4166(97)00573-9

The cyclic dipeptide cyclo[(R)-His-(R)-Phe] 1 has been known since 1981 to catalyze the enantioselective formation of cyanohydrins from aldehydes and HCN. Although 1 has proved to be very effective in the production of optically active cyanohydrins, the p