Journal of Heterocyclic Chemistry p. 1501 - 1510 (1997)
Update date:2022-08-03
Topics:
Ferrarini, Pier Luigi
Mori, Claudio
Badawneh, Muwaffag
Manera, Clementina
Martinelli, Adriano
Miceli, Mauro
Romagnoli, Federico
Saccomanni, Giuseppe
Several 1,8-naphthyridine derivatives have been diazotizated to obtain the corresponding hydroxy derivatives or mixture of hydroxy and hydroxy nitro derivatives. The respective amounts of hydroxy and hydroxy nitro derivatives depends on the nature of the substituents, on their position on the naphthyridine nucleus, on the amount of sodium nitrite and on the reaction temperature. A study of the electronic density of some molecules suggests a possible explanation of the effects induced by the nature of the substituents and of their position. Some of the compounds were tested for their ability to inhibit human platelet aggregation in vitro induced by arachidonic acid. Only compound 26 showed interesting antiplatelet activity.
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