Tetrahedron Letters p. 8803 - 8806 (1997)
Update date:2022-08-03
Topics:
Mlodnosky, Karyn L.
Holmes, H. Michael
Lam, Vinh Q.
Berkman, Clifford E.
Phosphonamidates are formed in high yield from a one-pot sequential reaction of a phosphonyl dichloride with an alcohol and then an amine in the presence of catalytic 1H-tetrazole. Undesired disubstitution of the phoshphonyl dichloride by the alcohol or the amine is minimal due to the presence of tetrazole.
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