Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors

DOI: 10.1016/S0960-894X(98)00386-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2235 - 2240 (1998)

Update date:2022-08-03

Topics:

Authors:

Buckman, Brad O.

Mohan, Raju

Koovakkat, Sunil

Liang, Amy

Trinh, Lan

Morrissey, Michael M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00386-2

The synthesis of amidinoaryloxy 9-benzyl-8-methyl-9H-purine, 7,8- dihydropteridine-6(5H)-one and 5,7-dihydropyrimido[4,5-b][1,4]oxazine-6-one inhibitors of Factor Xa is described. These compounds show nanomolar potency against FXa and maintain high selectivity over thrombin and trypsin.

Full text of DOI:10.1016/S0960-894X(98)00386-2

Products guided by the article

Product name:2-methylthio-4-chloro-5-nitro-6-(3-(dimethylaminocarbonyl)phenoxy)pyrimidine

Cas No:200011-85-4

R&D Labs maybe for 200011-85-4

Dalian Synco Chemical Co., Ltd.

Contact:+86-411-83635150

Address:Rm 1004, 24, Tangshan Street, Dalian
Xiamen Hisunny Chemical Co.,Ltd

website:http://www.hisunnychem.com

Contact:+86-592-3327115

Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China
Shanghai Yuanye Bio-Technology Co., Ltd.

website:http://www.shyuanye.com

Contact:+86-21-61845781

Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China
Zhejiang Sucon Silicone Co.,Ltd

Contact:+86-575-88046692

Address:Qisheng Rd., Paojiang Industrial Zone, Shaoxing, Zhejiang, China.
Synochem Ingredients Corp., Ltd.

Contact:+86-512-5636 2180

Address:Zhangjiagang Free Trade Zone

Relevant to this article

Doi:10.1021/jm00311a057
(1968)
Synthesis and Pharmacological Evaluation of Identified and Putative Metabolites of the A₁ Adenosine Receptor Antagonist 8-Cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (CPFPX)

Doi:10.1002/cmdc.201600592
(2017)
A convenient large-scale synthesis of ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazoline-3-yl)acetate

Doi:10.1002/prac.199733901136
(1997)
Computer-aided design, synthesis, and biological evaluation of 5-substituted aminomethylenepyrimidine-2,4,6-triones as H1 antihistaminic agents(Part2)

Doi:10.2174/15734064113099990032
(2014)
Chloroperoxidase-mediated asymmetric epoxidation. Synthesis of (R)- dimethyl 2-methylaziridine-1,2-dicarboxylate - A potential α-methylamino acid synthon

Doi:10.1016/S0957-4166(97)00467-9
(1997)
Restricted conformation analogues of an anthelmintic cyclodepsipeptide

Doi:10.1021/jm020482k
(2003)

Article Doi