Bioorganic and Medicinal Chemistry Letters p. 2235 - 2240 (1998)
Update date:2022-08-03
Topics:
Buckman, Brad O.
Mohan, Raju
Koovakkat, Sunil
Liang, Amy
Trinh, Lan
Morrissey, Michael M.
The synthesis of amidinoaryloxy 9-benzyl-8-methyl-9H-purine, 7,8- dihydropteridine-6(5H)-one and 5,7-dihydropyrimido[4,5-b][1,4]oxazine-6-one inhibitors of Factor Xa is described. These compounds show nanomolar potency against FXa and maintain high selectivity over thrombin and trypsin.
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