Bioorganic and Medicinal Chemistry Letters p. 2235 - 2240 (1998)
Update date:2022-08-03
Topics:
Buckman, Brad O.
Mohan, Raju
Koovakkat, Sunil
Liang, Amy
Trinh, Lan
Morrissey, Michael M.
The synthesis of amidinoaryloxy 9-benzyl-8-methyl-9H-purine, 7,8- dihydropteridine-6(5H)-one and 5,7-dihydropyrimido[4,5-b][1,4]oxazine-6-one inhibitors of Factor Xa is described. These compounds show nanomolar potency against FXa and maintain high selectivity over thrombin and trypsin.
View MoreXinchang Jiu Xin Pharmaceutical Co., Ltd
website:http://www.jiuxinpharm.com
Contact:86 137 5756 8585
Address:Poyang industry Park
HANGZHOU PANYU CHEMICAL CO.,LIMITED
Contact:+86-571-86578491
Address:Rm 605, NO.1870 Binsheng Road,Binjiang Dist, Hangzhou, China
shanghai Tauto Biotech Co., Ltd
website:http://www.tautobiotech.com/en/index.htm
Contact:+86-21-51320588 ext. 8025
Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA
ShiJiaZhuang Dowell Chemical Co.,Ltd.
website:http://www.dowechem.com
Contact:+86-13463963265
Address:Xiyangling village, high tech Zone, Shijiazhuang，Hebei, China
Shandong General Materials Co.,Ltd（Shandong Aoertong Chemical Co., Ltd）
Contact:86-531-88072280
Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
Doi:10.1021/jm00311a057
(1968)Doi:10.1002/cmdc.201600592
(2017)Doi:10.1002/prac.199733901136
(1997)Doi:10.2174/15734064113099990032
(2014)Doi:10.1016/S0957-4166(97)00467-9
(1997)Doi:10.1021/jm020482k
(2003)
