Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors

DOI: 10.1016/S0960-894X(98)00386-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2235 - 2240 (1998)

Update date:2022-08-03

Topics:

Authors:

Buckman, Brad O.

Mohan, Raju

Koovakkat, Sunil

Liang, Amy

Trinh, Lan

Morrissey, Michael M.

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Article abstract of DOI:10.1016/S0960-894X(98)00386-2

The synthesis of amidinoaryloxy 9-benzyl-8-methyl-9H-purine, 7,8- dihydropteridine-6(5H)-one and 5,7-dihydropyrimido[4,5-b][1,4]oxazine-6-one inhibitors of Factor Xa is described. These compounds show nanomolar potency against FXa and maintain high selectivity over thrombin and trypsin.

Full text of DOI:10.1016/S0960-894X(98)00386-2

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