Bioorganic and Medicinal Chemistry Letters p. 2635 - 2638 (1997)
Update date:2022-08-03
Topics:
Choy, Nakyen
Choi, Ho-Il
Jung, Won Hee
Kim, Chung Ryeol
Yoon, Heungsik
Kim, Sung Chun
Lee, Tae Gyu
Koh, Jong Sung
Novel irreversible HIV-1 protease inhibitors containing sulfonamide and sulfone as amide bond isosteres were designed, synthesized, and kinetically characterized. A representative compound 2 displayed rapid, time-dependent inactivation of HIV-1 protease and high potency in cell culture with IC50 of 6.6 nM.
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(2000)Doi:10.1002/jhet.5570310635
(1994)Doi:10.1055/s-1997-1368
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(2010)Doi:10.1039/a705571d
(1997)Doi:10.1007/BF02291796
(1997)
