Tetrahedron p. 7127 - 7166 (1998)
Update date:2022-08-05
Topics:
Nicolaou
Finlay, M. Ray V.
Ninkovic, Sacha
Sarabia, Francisco
The chemical synthesis of a series of 26-substituted epothilones B is described. Fully protected 26-hydroxydesoxy-epothilone B (7), prepared via the macrolactonization strategy, served as a common precursor to the designed epothilones described. The synthesized compounds were members of a large epothilone library whose biological screening led to the identification of a number of highly potent antitumor agents.
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