Nonclassical 5-substituted tetrahydroquinazolines as potential inhibitors of thymidylate synthase

DOI: 10.1002/jhet.5570340605

Source and publish data:

Journal of Heterocyclic Chemistry p. 1669 - 1676 (1997)

Update date:2022-08-05

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Authors:

Gangjee, Aleem

Vasudevan, Anil

Kisliuk, Roy L.

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Article abstract of DOI:10.1002/jhet.5570340605

Classical inhibitors of thymidylate synthase such as N¹⁰-propargyl- 5,8-dideazafolic acid (1), N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6- ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic acid (ZD1694, 2) and N-[2- amino-4-oxo-3,4-dihydro(py

Full text of DOI:10.1002/jhet.5570340605

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