Synthesis of 2'-deoxynucleoside 5'-methylenebis-(phosphonate)s using 2- (4-nitrophenyl)ethyl mthylene-bis(phosphonate) as the phosphonylating agent

Article abstract of DOI:10.1080/07328319808004723

2-(4-Nitrophenylethyl) methylenebis(phosphonate) (1) has been prepared by reaction of 2-(4-nitrophenyl)ethyl alcohol with methylenebis(phosphonyl) tetrachloride. Compound 1 was treated with diisopropylcarbodiimide (DIC) to give bicyclic intermediate 2, wh

Full text of DOI:10.1080/07328319808004723

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Synthesis of 2′-Deoxynucleoside
5′-Methylenebis-(phosphonate)s
Using 2-(4-Nitrophenyl)ethyl
Methylenebis(phosphonate) as the
Phosphonylating Agent.
Krystyna Lesiak a , Kyoichi A. Watanabe a & Krzysztof W. Pankiewicz
a
a Division of Medicinal Chemistry , Codon Pharmaceuticals, Inc. , 200
Perry Parkway, Gaithersburg, MD, 20877, U.S.A.
Published online: 22 Aug 2006.
To cite this article: Krystyna Lesiak , Kyoichi A. Watanabe & Krzysztof W. Pankiewicz (1998)
Synthesis of 2′-Deoxynucleoside 5′-Methylenebis-(phosphonate)s Using 2-(4-Nitrophenyl)ethyl
Methylenebis(phosphonate) as the Phosphonylating Agent., Nucleosides and Nucleotides, 17:9-11,
1857-1860, DOI: 10.1080/07328319808004723
To link to this article: http://dx.doi.org/10.1080/07328319808004723
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