
Tetrahedron Letters p. 669 - 672 (1998)
Update date:2022-08-05
Topics:
Robertson, Jeremy
Middleton, Donald S.
O'Connor, Garry
Sardharwala, Tsarina
Oxasilacyclopentanes 3, generated by either free-radical cyclisation, intramolecular hydrosilylation, or silicon tethered Diels-Alder reaction, may be efficiently opened with 2-propenyl-lithium and the product alcohols oxidised to prepare precursors 2 for silicon tethered ene cyclisation. Efficient and highly stereoselective ene reactions have been achieved with these precursors.
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