Tetrahedron Letters p. 1025 - 1028 (1998)
Update date:2022-08-03
Topics:
Mills Nee Davis, Catherine E.
Heightman, Thomas D.
Hermitage, Stephen A.
Moloney, Mark G.
Woods, Gordon A.
The synthesis of substituted [4.3.0] bicyclic lactams derived from 6- oxo-2-hydroxymethylpiperidine is described. The enolate derived flora these systems can be alkylated with a range of reactive electrophiles; the diastereoselectivity which can be achieved depends on the substitution pattern of the oxazolidine ring system and the nature of the alkylating reagent, and can vary from 1:1 to as much as 10:1.
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(2017)
