Bis-S-acyl-2-thioethyl (SATE)-bearing monophosphate prodrug of β-L-FD4C as potent anti-HBV agent

DOI: 10.1016/S0960-894X(97)10178-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 57 - 62 (1998)

Update date:2022-08-04

Topics:

Authors:

Li, Xiuyan

Carmichael, Ellen

Feng, Ming

King, Ivan

Doyle, Terrence W.

Chen, Shu-Hui

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Article abstract of DOI:10.1016/S0960-894X(97)10178-0

The S-acyl-2-thioethyl (SATE)-bearing 5'-monophosphate prodrug of β-L-FD4C (8) was synthesized and evaluated for its activity against HBV in the 2.2.15 cell line. This pronucleotide (8) exhibited an excellent inhibitory effect against HBV with an EC₅

Full text of DOI:10.1016/S0960-894X(97)10178-0

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