Bis-S-acyl-2-thioethyl (SATE)-bearing monophosphate prodrug of β-L-FD4C as potent anti-HBV agent

DOI: 10.1016/S0960-894X(97)10178-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 57 - 62 (1998)

Update date:2022-08-04

Topics:

Authors:

Li, Xiuyan

Carmichael, Ellen

Feng, Ming

King, Ivan

Doyle, Terrence W.

Chen, Shu-Hui

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)10178-0

The S-acyl-2-thioethyl (SATE)-bearing 5'-monophosphate prodrug of β-L-FD4C (8) was synthesized and evaluated for its activity against HBV in the 2.2.15 cell line. This pronucleotide (8) exhibited an excellent inhibitory effect against HBV with an EC₅

Full text of DOI:10.1016/S0960-894X(97)10178-0

Products guided by the article

Product name:{1-[(2S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-dihydro-furan-2-yl]-5-fluoro-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

Cas No:203635-01-2

R&D Labs maybe for 203635-01-2

Xinjiang Fufeng Biotechnologies Co., Ltd.

Contact:+86-539-7287111

Address:GANQUANPU INDUSTRIAL PARK, ECONOMIC AND TECHNOLOGICAL DEVELOPMENT AREA (TOUTUNHE DISTRICT) OF URUMQI
SHANGHAI ARCADIA BIOTECHNOLOGY LTD.

Contact:+86-21-61353236

Address:SUITE 901, BUILDING WENSLI, 1378 LU JIA BANG RD, SHANGAHI 200011, P.R.CHINA
Chengdu Green Young Biopharmaceutical INC

Contact:+86-28-85337952

Address:1-B-26,Tianhe Industry Park, No.1480 of Tianfu Road,Chengdu,P.R.China,610000
Shanghai Yudiao Chemistry Technology Co.,Ltd

Contact:0086-18964703211

Address:Building NO.5, NO.218,Rongtian Road,ganxiang town,Jinshan District,shanghai,201518,china
GLD peptide scientific lnc.

Contact:21-7631221 15884421033

Address:326 Science and technology,Shanghai,China

Relevant to this article

Mandelonitrile in synthesis of partially hydrogenated isoquinoline derivatives

Doi:10.1134/S107042721008032X
(2010)
Regioselective Ni-Catalyzed Carboxylation of Allylic and Propargylic Alcohols with Carbon Dioxide

Doi:10.1021/acs.orglett.7b01208
(2017)
Pyridine Syntheses. II. Condensation Routes Toward Streptonigrin Ring C [1]

Doi:10.1002/jhet.5570350113
(1998)
Carboxy-substituted cinnamides: A novel series of potent, orally active LTB₄ receptor antagonists

Doi:10.1021/jm980540v
(1999)
Structure-activity relationship studies on N³-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists

Doi:10.1021/jm051086f
(2006)
Synthesis of pentaarabinofuranosyl structure motif A of Mycobacterium tuberculosis

Doi:10.1039/a707796c
(1998)

Article Doi