Towards the semi-synthesis of didemnin M. solution and solid phase synthesis of the pseudotetrapeptide: pGlu-Glnψ[COO]Ala-Pro-OH

Article abstract of DOI:10.1016/S0040-4039(97)10609-8

Two approaches, solution and solid phase syntheses, were developed for the synthesis of the pseudotetrapeptide, pGlu-Glnψ[COO]Ala-Pro-OH. Both approaches gave comparable synthetic yields, but the latter approach provided an expedient entry to the synthesis of the target compound with higher product purity.