Tetrahedron Letters p. 857 - 860 (1998)
Update date:2022-08-03
Topics:
Langlois, Nicole
Radom, Marie-Odile
The highly stereoselective synthesis of (2S,3S)-3-N-benzylaminoprolinol and derivatives involved the conjugate addition of N-benzylamine to α,β-unsaturated lactam 2. Wittig-Horner reactions with 1-acetyl-3-N-acetyl-N-benzylaminoprolinal provided a simple access to (7S,8R)-7-N-benzylaminopyrrolizidin-3-one.
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