First total synthesis of 1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines

DOI: 10.1016/S0040-4039(97)10737-7

Source and publish data:

Tetrahedron Letters p. 1231 - 1232 (1998)

Update date:2022-08-04

Topics:

Authors:

Martinez, Elena

Estevez, Juan C.

Estevez, Ramon J.

Villaverde, M. Carmen

Castedo, Luis

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Article abstract of DOI:10.1016/S0040-4039(97)10737-7

Here we describe the first total synthesis of 1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines (7) from N-acyl-o-styrylphenylethylamines 3. It proceeds by the Bischler-Napieralski reaction to form the isoquinoline unit and photocyclization of the resulting 5-styrylisoquinolines.

Full text of DOI:10.1016/S0040-4039(97)10737-7

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Product name:1-Methyl-5-((E)-styryl)-1,2,3,4-tetrahydro-isoquinoline

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