Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology.

DOI: 10.1016/S0960-894X(98)00004-3

Source and publish data:

Bioorganic and medicinal chemistry letters p. 267 - 272 (1998)

Update date:2022-08-04

Topics:

Authors:

Freyne Freyne

Raeymaekers

Venet Venet

Sanz Sanz

Wouters Wouters

De Coster

Wauwe Wauwe

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Article abstract of DOI:10.1016/S0960-894X(98)00004-3

The synthesis of LIAZAL (compound 9, R085246) is described. LIAZAL inhibits all-trans-retinoic acid metabolism and thereby exerts retinoid-like effects in vivo.

Full text of DOI:10.1016/S0960-894X(98)00004-3

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