Cascade radical processes leading to polycycle constructions. The total synthesis of spongian-16-one

Article abstract of DOI:10.1016/0040-4039(96)00740-X

A concise total synthesis of the marine sponge metabolite spongian-16-one 1, which features a novel cascade of three consecutive 6-endo-trig radical cyclisations from a polyene acyl radical intermediate as a key step, viz 9 → 10, is described.