Bioorganic and Medicinal Chemistry Letters p. 133 - 138 (1998)
Update date:2022-08-03
Topics:
Drysdale, Martin J.
Reinhard, John F.
A series of 2-amino-S-aryl cysteine S,S-dioxides have been synthesised and shown to inhibit kynureninase an important enzyme in the biosynthesis of the known excitotoxic moiety quinolinic acid. The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-γ induced synthesis of quinolinic acid in human macrophages.
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(1998)
