2'-Deoxy-2'(S)-ethynyl oligonucleotides: Synthesis and pairing properties

Article abstract of DOI:10.1080/07328319908044725

Oligonucleotides from 2'-deoxy-2'(S)-ethinyl-adenosine, -cytidine, - guanosine, -thymidine and -uridine have been prepared. Whereas the modified pyrimidine oligonucleotides uniformly lead to weaker binding affinity with DNA and RNA complements, the corresponding adenine oligonucleotides show enhanced thermal stability in duplexes with complementary DNA and decreased stability with RNA.

Full text of DOI:10.1080/07328319908044725

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Nucleosides and Nucleotides
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2′-Deoxy-2′(S)-ethynyl Oligonucleotides:
Synthesis and Pairing Properties
Rolf Buff a & Jürg Hunziker a
a Department of Chemistry and Biochemistry , University of Bern ,
Freiestrasse 3, 3012, Bern, Switzerland
Published online: 04 Oct 2006.
To cite this article: Rolf Buff & Jürg Hunziker (1999) 2′-Deoxy-2′(S)-ethynyl Oligonucleotides:
Synthesis and Pairing Properties, Nucleosides and Nucleotides, 18:6-7, 1387-1388
To link to this article: http://dx.doi.org/10.1080/07328319908044725
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