The synthesis of several tritiated non-nucleoside, HIV-1 reverse transcriptase inhibitors

Article abstract of DOI:10.1002/(SICI)1099-1344(199804)41:4<319::AID-JLCR84>3.0.CO;2-S

The synthesis of three tritiated reverse transcriptase inhibitors is described herein. These compounds contained the benzoxazole ring linked to a 2-pyridinone ring by an aminomethylene group. The tritiated compounds were synthesized by hydrogenolysis of bromobenzoxazole precursors. The final tritiated compounds had specific activities ranging from 3-10 Cl/mmol.