Syntheses and kinetic evaluation of hydroxamate-based peptide inhibitors of glyoxalase I

DOI: 10.1016/S0960-894X(98)00116-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 705 - 710 (1998)

Update date:2022-07-29

Topics:

Authors:

Ly, Hoa D.

Clugston, Susan L.

Sampson, Peter B.

Honek, John F.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00116-4

Hydroxamate-containing tripeptide analogs resembling a reactive intermediate in glyoxalase I catalysis were prepared by solution methods and were found to be competitive inhibitors of the enzyme from Saccharomyces cerevisiae. Electronic properties of the hydroxamate functionality as well as those of the expected intermediates in the enzyme-catalyzed reaction were compared.

Full text of DOI:10.1016/S0960-894X(98)00116-4

Products guided by the article

Product name:(S)-2-tert-Butoxycarbonylamino-4-[(S)-3-carboxy-1-(ethoxycarbonylmethyl-carbamoyl)-propylcarbamoyl]-butyric acid tert-butyl ester

Cas No:205812-43-7

R&D Labs maybe for 205812-43-7

Aminodiscovery Co.,Ltd.

Contact:+86-535-8888888

Address:No.161 Haishi Rd.
Changzhou Welton Chemical Co., Ltd,

Contact:0086-519-85910828,85920537,85912897

Address:No.8 Jinlong Road, Binjiang Park, Changzhou, Jiangsu, China.
Angel Yeast Co., Ltd.

Contact:+86-717-6370352

Address:168 Chengdong Avenue, Yichang, Hubei 443003, P. R.China
Hangzhou Zhenghan Biological Technology Co., Ltd.

Contact:86-571-88781753

Address:liangzhu yuhang hangzhou city
Jinan Great Chemical Co.,Ltd.

Contact:+86-531-58668191 58668193 58668196 58661173

Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province

Relevant to this article

Ruthenium-mediated selective head-to-tail dimerization of acrylic and α,β-unsaturated carbonyl compounds: Generation of an acrylate-hydride complex C₅Me₅Ru(PCy₃)(CH₂=CHCO ₂Et)H

Doi:10.1016/S0022-328X(97)00591-3
(1998)
Doi:10.1021/jm00310a038
(1968)
Synthetic Studies on Dynemicin A. New Quinoline Synthesis for C, D and E Rings

Doi:10.1016/S0040-4020(01)85633-7
(1994)
Enzymes in organic chemistry VI [1]. Enantioselective hydrolysis of 1-chloroacetoxycycloalkylmethylphosphonates with lipase AP 6 from Aspergillus niger and chemoenzymatic synthesis of chiral, nonracemic 1-aminocyclohexyl-methylphosphonic acids

Doi:10.1007/PL00000099
(1998)
Pd/Cu-catalyzed couplings of β-amino esters with aryl bromides. Synthesis of chiral 1,2,3,4-tetrahydro-4-oxo-2-alkyl-1-quinolines

Doi:10.1016/S0957-4166(98)00078-0
(1998)
Asymmetric synthesis of a cytotoxic amide of Telesto riisei

Doi:10.1016/S0957-4166(98)00091-3
(1998)

Article Doi