Bioorganic and Medicinal Chemistry Letters p. 983 - 988 (1998)
Update date:2022-07-29
Topics:
Maryanoff, Bruce E.
McComsey, David F.
Martin, Gregory E.
Shank, Richard P.
We synthesized 20 and 21 as conformationally constrained analogues of the dopamine receptor antagonist SKF-83742, as well as analogues 6-9, 16, and 18-22. Although 20 and 21 were inactive, 7, 9, and 19 showed strong binding to D-1, D-2, S-2, and α-1 receptors, as well as antipsychotic activity in vivo.
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