Bioorganic and Medicinal Chemistry Letters p. 983 - 988 (1998)
Update date:2022-07-29
Topics:
Maryanoff, Bruce E.
McComsey, David F.
Martin, Gregory E.
Shank, Richard P.
We synthesized 20 and 21 as conformationally constrained analogues of the dopamine receptor antagonist SKF-83742, as well as analogues 6-9, 16, and 18-22. Although 20 and 21 were inactive, 7, 9, and 19 showed strong binding to D-1, D-2, S-2, and α-1 receptors, as well as antipsychotic activity in vivo.
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Doi:10.1021/jo00111a037
(1995)Doi:10.1021/ja00400a053
(1981)Doi:10.1021/ja01022a034
(1968)Doi:10.1021/np9704922
(1998)Doi:10.1016/S0040-4039(98)00735-7
(1998)Doi:10.1021/jm00314a042
(1967)
