Chemical and Pharmaceutical Bulletin p. 697 - 703 (1998)
Update date:2022-08-03
Topics:
Asagarasu, Akira
Uchiyama, Taketo
Achiwa, Kazuo
Some HIV-protease inhibitor derivatives having an N- carbomethoxycarbonyl-prolyl-phenylalanine benzyl ester (CPF) moiety as a binding site to gp120 were designed and synthesized. Almost all the compounds bearing CPF on the phenoxyacetyl group showed protease-inhibitory activity. Compounds 25a and 25b, which have the CPF moiety at the ortho- and meta- positions of the phenoxyacetyl group, respectively, had anti-HIV activity, although the others showed only protease-inhibitory activity. These results suggest that 25b binds to gp120 and inhibits HIV protease.
View MoreJiangxi Lanqi Fine Chemical S&T Co., Ltd.
Contact:+86-21-64891143
Address:XinJiShan Industrial Area, Zhangshu City, JiangXi Province, China
Nanjing Fayekong Chemcial Co.,Ltd(expird)
Contact:86-25-58813444
Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
Zibo Kunran Enterprises Co. LTD
website:http://www.kunranchem.com
Contact:0086 533 5200669
Address:No. 96 Jinjing Avenue, Zibo, Shandong, China
Guangxi Bonger Pharmaceutical Co., Ltd
website:http://napo.lookchem.com/
Contact:+86-18817331185
Address:Donghai Industrial Zone, Tiandong Country,Guangxi,China
website:http://www.guarson.com
Contact:+86-523-88059600,+86-13805268803
Address:Room B1006,Yafang Building,Jiangyan Avenue,Jiangyan District, Taizhou City,Jiangsu,China
Doi:10.1016/S0040-4039(98)00249-4
(1998)Doi:10.1039/a702794j
(1998)Doi:10.1002/hlca.19980810502
(1998)Doi:10.1016/S0040-4039(98)00495-X
(1998)Doi:10.1007/BF01149156
(1981)Doi:10.1021/jm0704189
(2007)
