Tetrahedron p. 4591 - 4606 (1998)
Update date:2022-08-03
Topics:
Horwell, David C.
Lewthwaite, Russell A.
Pritchard, Martyn C.
Ratcliffe, Giles S.
Rubin, J. Ronald
A series of piperazinone ring systems have been synthesized as a means of evaluating the effect of conformational restriction of high affinity non-peptide NK1, NK3 and CCK-B receptor ligands.The synthesis of the targeted heterocycles is described along with a discussion of their affinities for their respective receptor types.
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