Stereoselective synthesis of 6,5-bicyclic reverse-turn peptidomimetics

DOI: 10.1016/S0040-4020(98)00207-5

Source and publish data:

Tetrahedron p. 5325 - 5336 (1998)

Update date:2022-08-03

Topics:

Authors:

Colombo, Lino

Di Giacomo, Marcello

Brusotti, Gloria

Sardone, Nicola

Angiolini, Mauro

Belvisi, Laura

Maffioli, Sonia

Manzoni, Leonardo

Scolastico, Carlo

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Article abstract of DOI:10.1016/S0040-4020(98)00207-5

A flexible stereoselective synthetic scheme was developed to prepare 6,5-fused bicyclic lactams, that molecular mechanics calculations revealed to have a potential as reverse-turn mimetics. The convergence of the synthetic sequence was achieved by attachm

Full text of DOI:10.1016/S0040-4020(98)00207-5

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