Stereoselective synthesis of 6,5-bicyclic reverse-turn peptidomimetics

Article abstract of DOI:10.1016/S0040-4020(98)00207-5

A flexible stereoselective synthetic scheme was developed to prepare 6,5-fused bicyclic lactams, that molecular mechanics calculations revealed to have a potential as reverse-turn mimetics. The convergence of the synthetic sequence was achieved by attachm