Effect of acridine with various linker arms attached to C5 position of 2'-deoxyuridine on the stability of DNA/DNA and DNA/RNA duplexes

Article abstract of DOI:10.1080/07328319808003463

Acridine-modified oligodeoxyribonudeotides (ODNs) at the C5-position of a 2'-deoxyuridine via different lengths of linker arms were synthesized. Reaction of 5-(N-aminoalkyl)carbamoylmethyl-2'-deoxyuridines with 9- phenoxyacridine gave the acridine-modified 2'-deoxyuridines which were incorporated into ODNs. The duplexes containing the acridine-modified strands and their complementary DNA or RNA were thermally more stable than that containing the unmodified strand. Thermal stability of the duplexes of the modified ODNs varied depending on the length of the linker arms.

Full text of DOI:10.1080/07328319808003463

Nucleosides and Nucleotides
ISSN: 0732-8311 (Print) (Online) Journal homepage: http://www.tandfonline.com/loi/lncn19
Effect of Acridine with Various Linker Arms
Attached to C5 Position of 2′-Deoxyuridine on the
Stability of DNA/DNA and DNA/RNA Duplexes
Hiroaki Ozaki , Yoshinori Ogawa , Masayuki Mine & Hiroaki Sawai
To cite this article: Hiroaki Ozaki , Yoshinori Ogawa , Masayuki Mine & Hiroaki Sawai (1998)
Effect of Acridine with Various Linker Arms Attached to C5 Position of 2′-Deoxyuridine on the
Stability of DNA/DNA and DNA/RNA Duplexes, Nucleosides and Nucleotides, 17:5, 911-923,
DOI: 10.1080/07328319808003463
To link to this article: http://dx.doi.org/10.1080/07328319808003463
Published online: 21 Aug 2006.
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Date: 24 January 2016, At: 00:30