Novel carbocyclic nucleosides containing a cyclobutyl ring. Guanosine and adenosine analogues

Article abstract of DOI:10.1080/07328319808004236

(1R,cis)-2-(3-Amino-2,2-dimethylcyclobutyl)ethanol (4) was used as a precursor in the synthesis of cyclobutyl nucleoside analogues containing guanine, 8-azaguanine, adenine or 8-azaadenine. All the compounds were evaluated as antiviral agents in a variety of assay systems. Some activity was noted for compound 13, 17, 19 and 20 against vaccinia virus and for compounds 11, 12, 13, 17, 19 and 20 against herpes simplex virus, at concentrations that were up to 10-fold below the cytotoxic concentrations for the host cells.

Full text of DOI:10.1080/07328319808004236

Nucleosides and Nucleotides
ISSN: 0732-8311 (Print) (Online) Journal homepage: http://www.tandfonline.com/loi/lncn19
Novel Carbocyclic Nucleosides Containing A
Cyclobutyl Ring. Guanosine and Adenosine
Analogues
José E. R. Borges , Franco Fernández , Xerardo García , Antonio R. Hergueta ,
Carmen López , Graciela Andrei , Robert Snoeck , Myriam Witvrounw , Jan
Balzarini & Erik De Clercq
To cite this article: José E. R. Borges , Franco Fernández , Xerardo García , Antonio R.
Hergueta , Carmen López , Graciela Andrei , Robert Snoeck , Myriam Witvrounw , Jan
Balzarini & Erik De Clercq (1998) Novel Carbocyclic Nucleosides Containing A Cyclobutyl Ring.
Guanosine and Adenosine Analogues, Nucleosides and Nucleotides, 17:7, 1237-1253, DOI:
10.1080/07328319808004236
To link to this article: http://dx.doi.org/10.1080/07328319808004236
Published online: 21 Aug 2006.
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Date: 02 February 2016, At: 03:20