Synthesis and biological evaluation of a water soluble phosphate prodrug of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP)

DOI: 10.1016/S0960-894X(98)00573-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3159 - 3164 (1998)

Update date:2022-08-04

Topics:

Authors:

Li, Jun Li, Jun

Luo, Xiang

Wang, Qin

Zheng, Li-Mou

King King

Doyle, Terrence W.

Chen, Shu-Hui

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00573-3

With the aim of improving its biological and pharmaceutical profiles, two water soluble phosphate prodrugs of 3-AP, 3a and 3b were prepared. The detailed synthesis and the preliminary evaluation of these prodrugs are described.

Full text of DOI:10.1016/S0960-894X(98)00573-3

Products guided by the article

Product name:4-(Hydroxymethyl)phenyl bis(2-(trimethylsilyl)ethyl)phosphate

Cas No:208983-72-6

R&D Labs maybe for 208983-72-6

China Synchem Technology Co.,Ltd

website:http://www.cnsynchem.com

Contact:+86-0552-4929311

Address:No.217 Daqing Road
TLS PHARMACEUTICAL CO.,LTD

Contact:0833-5590788/5590338/5590055

Address:Victory in the town of Red Star Village,Mount Emei City,industrial concentration area storage processing logistics parkpark
Xiamen Kaijia Imp & Exp Co., Ltd.

Contact:86-592-5101177

Address:Room406 Luhui Building No. 65 Haitian Road Huli Xiamen,China.
Lishui Nanming Chemical Co., Ltd(expird)

Contact:+86-0578-2134101，2697830

Address:No.19 Tongji Road Shuige Industrial zone
Lanling Hongchuang Flame Retardant Co., Ltd.

Contact:+86-531-68858132

Address:East Huafeichang Road, Cangshan County, Linyi, Shandong, China (Mainland)

Relevant to this article

A straightforward preparation of chiral 5-(aminomethyl)oxazole derivatives from α-amino esters and α-lithiated isocyanides

Doi:10.1248/cpb.46.860
(1998)
8-Azaadenosine and its 2'-deoxyribonucleoside: Synthesis and oligonucleotide base-pair stability

Doi:10.1002/hlca.19980810527
(1998)
Chemoselective syntheses of various cyanofluoromethylene compounds from organic bromides by use of sodium triethylgermanate(IV) and its mechanistic studies

Doi:10.1055/s-1999-3438
(1999)
Intramolecular N-H?H-Ru proton-hydride interaction in ruthenium complexes with (2-(dimethylamino)ethyl)cyclopentadienyl and (3-(dimethylamino)propyl)cyclopentadienyl ligands. Hydrogenation of CO₂ to formic acid via the N-H?H-Ru hydrogen-bonded complexes

Doi:10.1021/om980071v
(1998)
Doi:10.1016/S0040-4020(01)93868-2
(1972)
Alkoxymesitylchlorogermanes and aryloxymesitylchlorogermanes

Doi:10.1016/S0020-1693(97)06137-9
(1998)

Article Doi