Synthesis and biological evaluation of a water soluble phosphate prodrug of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP)

DOI: 10.1016/S0960-894X(98)00573-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3159 - 3164 (1998)

Update date:2022-08-04

Topics:

Authors:

Li, Jun Li, Jun

Luo, Xiang

Wang, Qin

Zheng, Li-Mou

King King

Doyle, Terrence W.

Chen, Shu-Hui

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Article abstract of DOI:10.1016/S0960-894X(98)00573-3

With the aim of improving its biological and pharmaceutical profiles, two water soluble phosphate prodrugs of 3-AP, 3a and 3b were prepared. The detailed synthesis and the preliminary evaluation of these prodrugs are described.

Full text of DOI:10.1016/S0960-894X(98)00573-3

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Product name:4-(Hydroxymethyl)phenyl bis(2-(trimethylsilyl)ethyl)phosphate

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