Design and Synthesis of Peptide Derivatives of a 3-Deoxy-D-manno-2-octulosonic Acid (KDO) Analogues as Novel Antibacterial Agents Acting upon Lipopolysaccharide Biosynthesis

Article abstract of DOI:10.1021/jm00395a022

On the basis of the knowledge that the amino acid 3 (8-amino-2,6-anhydro-3,8-dideoxy-D-glycero-D-talo-octonic acid) is a potent inhibitor of 3-deoxy-manno-octulosonate cytidylyltransferase, attempts were made to design derivatives that would act as antiba