8-Fluoro-6-(methoxymethoxy)quinoline: Synthesis and Regioselective Functionalization via Reaction with Organolithium Compounds

DOI: 10.1002/hlca.19980810522

Source and publish data:

Helvetica Chimica Acta p. 1088 - 1094 (1998)

Update date:2022-08-02

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Authors:

Stadlwieser, Josef

Barbier, Pierre

Taylor, Sven

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Article abstract of DOI:10.1002/hlca.19980810522

8-Fluoro-6-(methoxymethoxy)quinoline (1) was synthesized, and the reactivity of 1 against organolithium compounds was studied under different reaction conditions. With BuLi, directed ortho-metalation (DoM) was accompanied by 1,2-addition to the C=N bond.

Full text of DOI:10.1002/hlca.19980810522

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