Bioorganic and Medicinal Chemistry Letters p. 2299 - 2302 (1997)
Update date:2022-08-03
Topics:
Broadhurst
Brown
Lawton
Ballantyne
Borkakoti
Bottomley
Cooper
Eatherton
Kilford
Malsher
Nixon
Lewis
Sutton
Johnson
A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage protective agent for use in the treatment of rheumatoid- and osteoarthritis.
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