Synthesis p. 3493 - 3498 (2018)
Update date:2022-07-29
Topics:
Espinoza-Hicks, José C.
Zaragoza-Galán, Gerardo
Chávez-Flores, David
Ramos-Sánchez, Víctor H.
Tamariz, Joaquín
Camacho-Dávila, Alejandro A.
An efficient, general synthetic protocol for the synthesis of the biologically active benzofurans ailanthoidol, egonol and homoegonol was developed. The key starting material, eugenol, is a naturally occurring and abundant precursor. The protocol, involving sequential acylation and intramolecular Wittig reaction, provides a convenient method for building the benzofuran moiety in good yield.
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