High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template

DOI: 10.1016/S0960-894X(98)00215-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1343 - 1348 (1998)

Update date:2022-08-05

Topics:

Authors:

Harrison

Korsgaard

Swain Swain

Cascieri

Sadowski

Seabrook

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00215-7

High affinity, selective hNK₂ or hNK₃ ligands can be prepared from the common template 1 in a few simple chemical operations. The hNK₃ ligands 3 antagonise the calcium mobilisation caused by activation of hNK₃ receptors expressed in CHO cells as measured using fura-2 microspectrofluorimetry.

Full text of DOI:10.1016/S0960-894X(98)00215-7

Products guided by the article

Product name:Methanesulfonic acid 3-[1-benzyl-3-(3,4-dichloro-phenyl)-6-oxo-piperidin-3-yl]-propyl ester

Cas No:210545-37-2

R&D Labs maybe for 210545-37-2

Zhuhai Rundu Pharmaceutical co.,Ltd

Contact:+86-756-7630755

Address:No.6,North Airport Road,Sanzao Town,Jinwan District
zhuzhou zhongle chemical co. ltd.

Contact:+86-0731 28228409

Address:Zhuzhou, Hunan, China
Tianjin Dongchang Fine Chemical Industry Co., Ltd.

Contact:+86-22-29894595

Address:Economic Developing Zone, Ji County, Tianjin, China
JIANGSU GRAND XINYI PHARMACEUTICAL CO.,LTD

website:http://www.xypharm.com/

Contact:+86-515-84383317

Address:Chenli Road,Costal Chemical Area Binhai,Yancheng, Jiangsu,China
TIANJIN FESTO CHEMICAL CO.,LTD(expird)

Contact:86-22-25814570

Address:No.12th,5th Ave.,TEDA,Tianjin,China

Relevant to this article

Enantiospecific synthesis of (+)-pinguisenol, (+)-pinguisen-10-one and (-)-pinguisen-8,10-dione

Doi:10.1016/S0040-4039(98)00891-0
(1998)
Photochemistry of ring-coupled group VI bimetallic compounds I: Phosphine substitution without disproportionation. The molecular structures of Mo₂(CO)₅[P(C₆H₅)₃] (μ-η⁵,η⁵-C₅H₄-CR₂-C₅H₄).

Doi:10.1016/S0022-328X(98)00396-9
(1998)
Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8. Synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential α₁-adrenoceptor antagonists

Doi:10.1021/jm970159v
(1998)
Synthesis and characterization of OsX{NH=C(Ph)C₆H₄}H₂(PⁱPr ₃)₂ (X = H, Cl, Br, I): Nature of the H₂ unit and its behavior in solution

Doi:10.1021/om9802820
(1998)
First glycosylation of decarestrictine B and D: A route to hybrid antibiotics

Doi:10.1002/(SICI)1521-3765(19980710)4:7<1324::AID-CHEM1324>3.0.CO;2-6
(1998)
An efficient new protocol for the formation of unsymmetrical Tri-and tetrasubstituted ureas

Doi:10.1016/S0040-4039(98)01330-6
(1998)

Article Doi