High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template

DOI: 10.1016/S0960-894X(98)00215-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1343 - 1348 (1998)

Update date:2022-08-05

Topics:

Authors:

Harrison

Korsgaard

Swain Swain

Cascieri

Sadowski

Seabrook

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Article abstract of DOI:10.1016/S0960-894X(98)00215-7

High affinity, selective hNK₂ or hNK₃ ligands can be prepared from the common template 1 in a few simple chemical operations. The hNK₃ ligands 3 antagonise the calcium mobilisation caused by activation of hNK₃ receptors expressed in CHO cells as measured using fura-2 microspectrofluorimetry.

Full text of DOI:10.1016/S0960-894X(98)00215-7

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