Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors

Article abstract of DOI:10.1016/S0960-894X(98)00597-6

A series of succinyl hydroxamate MMP inhibitors were prepared incorporating an aryl amino ketone moiety in place of the more typical C- terminal amino acid amides. Compounds of the C-terminal ketone series displayed potent inhibition of MMPs. Several comp