Rapid synthesis of a 5'-fluorinated oligodeoxy-nucleotide: A model antisense probe for use in imaging with positron emission tomography (PET)

DOI: 10.1016/S0960-894X(98)00239-X

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Bioorganic and Medicinal Chemistry Letters p. 1317 - 1320 (1998)

Update date:2022-08-05

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Authors:

Pan, Dongfeng

Gambhir, Sanjiv S.

Toyokuni, Tatsushi

Iyer, Meera R.

Acharya, Naveen

Phelps, Michael E.

Barrio, Jorge R.

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Article abstract of DOI:10.1016/S0960-894X(98)00239-X

5'-Deoxy-5'-fluoro-O⁴-methylthymidine was synthesized by the reaction of the corresponding 5'-O-tosylate with KF in the presence of Kryptofix [222] and coupled to a 5'-phosphoramidite-activated CPG-bound oligodeoxynucleotide. The sequence of re

Full text of DOI:10.1016/S0960-894X(98)00239-X

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