Bioorganic and Medicinal Chemistry Letters p. 1455 - 1460 (1998)
Update date:2022-07-30
Topics:
Petric, Andrej
Jacobson, Andrew F.
Barrio, Jorge R.
Functionalization of a viscosity-sensitive visible wavelength fluorophore 2-(1,1-dicyanopropenyl-2)-6-dimethylaminonaphthalene (DDNP), with the intent to incorporate its favorable optical properties into a probe for structural and functional imaging by fluorescence microscopy, is described. Spiperone, a highly potent ligand for the dopamine D2 receptors, was conjugated via an ethylpiperazine moiety to the fluorophore giving fluorescent probes that can be excited in the UV and Vis range.
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