Bioorganic and Medicinal Chemistry Letters p. 719 - 724 (1996)
Update date:2022-08-05
Topics: HIV protease inhibitors
Hamilton, Harriet W.
Tait, Bradley D.
Gajda, Christopher
Hagen, Susan E.
Ferguson, Donna
Lunney, Elizabeth A.
Pavlovsky, Alexander
Tummino, Peter J.
Publications from our laboratories have recently described a series of 3-thioaryl substituted-4-hydroxy-pyrones as HIV protease inhibitors. The current work examines the analogues 5,6-dihydro-2H-pyran-2-ones with 6,6-substitutions focusing on the use of 1
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