Epsilon-lactam analogs of the anthelmintic cyclodepsipeptide PF1022A

Article abstract of DOI:10.1016/S0040-4039(98)01075-2

Conformationally restricted analogs of the anthelmintic cyclodepsipeptide PF1022A 1 were prepared by fusing a seven-membered lactam ring onto the macrocycle. Following the preparation of cyclodepsipeptide (CDP) 2 by classical chemical methods, CDPs 2 and 3 were synthesized using solid phase methodology involving cyclization-cleavage from an oxime resin.